TY - CHAP M1 - Book, Section TI - Stroke A1 - Starr, Jessica A1 - Rowan, Brea A2 - Sutton, S. Scott Y1 - 2019 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - Ischemic stroke is an acute onset of focal neurological deficit that involves permanent infarction of central nervous system tissue. A transient ischemic attack (TIA) is similar to ischemic stroke but is caused by focal brain, spinal cord, or retinal ischemia without acute infarction. Cranial occlusions result from an embolus formed in the carotid arteries or the ventricles of the heart. Atherosclerosis of the carotid arteries leads to plaque formation and if plaque ruptures, collagen is exposed resulting in platelet aggregation and thrombus formation. The clot may break off and cause cranial vessel occlusion (decreased blood flow to the brain region it supplies) resulting in ischemia. Strokes originating from a cardioembolic source are presumed to originate from thrombus formation in the left ventricle. Clinical presentation includes weakness on one side of the body, visual impairment, and inability to speak. Diagnosis is confirmed via computed tomography (CT) scanning and magnetic resonance imaging (MRI). Risk factors for an ischemic stroke include hypertension, dyslipidemia, diabetes, cigarette smoking, and atrial fibrillation (Table 6-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158313473 ER -