TY - CHAP M1 - Book, Section TI - Oncology Overview and Supportive Care A1 - Hecht, Keith A. A2 - Sutton, S. Scott Y1 - 2019 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - Modern medical science has led to significant improvement in survival and quality of life for individuals with neoplastic (neoplasm) conditions. Neoplasm (tumor or cancer) is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissues and persists after cessation of the stimuli which evoked the change. The key feature of cancer is unregulated cell division and growth, secondary to the loss of normal control mechanisms that govern cell survival, proliferation, and differentiation. Benign tumors are limited to the tissue of origin and do not invade surrounding tissue. Their dangerous counterpart, malignant tumors can invade local tissues and undergo distant spread (metastasis). Malignant tumors (often referred to as cancer) are predominantly of two types, solid tumors and hematologic malignancies. Solid tumors include various types of cancer, typically arising from a specific organ or site. They are characterized by their initial location as well as their cell of origin, including carcinomas (of epithelial origin) and the sarcomas (of connective tissue origin, mesenchymal origin). Hematologic malignancies include cancers that arise from cells in the hematopoietic cascade and are most commonly categorized as leukemias, lymphomas, or myeloma. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158313722 ER -