TY  - CHAP
M1  - Book, Section
TI  - Estimating Renal Function
A1  - Bland, Christopher M.
A1  - Jenkins, Caitlin
A1  - Scott Sutton, S.
A2  - Sutton, S. Scott
Y1  - 2019
N1  - 
T2  - McGraw-Hill's NAPLEX® Review Guide, 3e
AB  - Estimating  renal  function  is  important  for  patients  taking  renally  eliminated  medications  in  order  to  maximize  effectiveness  while  limiting  toxicity.  The  glomerular  filtration  rate  (GFR)  is  an  effective  indicator  of  renal  function  and  normal  values  are  approximately  130  mL/min/1.73  m2  for  men  and  120  mL/min/1.73  m2  for  women.  The  gold  standard  for  approximating  GFR  is  the  inulin  clearance  method.  Inulin  is  filtered  by  the  glomerulus  and  is  not  secreted  or  reabsorbed,  making  it  an  ideal  agent  for  approximating  GFR.  The  inulin  clearance  method  is  rarely  done  because  it  is  costly,  invasive,  and  requires  technical  expertise.  Additional  markers  used  to  estimate  GFR  include  iothalamate,  iohexol,  and  ethylenediaminetetraacetic  acid.  Like  inulin,  these  markers  are  expensive  and  have  limited  availability,  making  them  impractical  in  the  clinical  setting.  Numerous  methods  have  been  developed  to  estimate  GFR  and  examples  include  the  Cockcroft-Gault  and  the  Modification  of  Diet  in  Renal  Disease  (MDRD)  equations.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1158314884
ER  -