TY - CHAP M1 - Book, Section TI - Acute Kidney Injury A1 - Branan, Trisha N. A1 - Hawkins, W. Anthony A2 - Sutton, S. Scott Y1 - 2019 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - Acute kidney injury (AKI) occurs when there is a sudden and significant decrease in kidney function. An increase in the serum creatinine (SCr) concentration is the result of accumulation due to a decrease in the glomerular filtration rate (GFR). The diagnosis of AKI is based on the change in SCr from baseline and/or changes in urinary output (UOP). AKI can occur because the kidneys are vulnerable to certain types of injury. First, they are dependent upon the heart and vasculature to deliver sufficient blood supply to drive glomerular filtration. Second, they are exposed to numerous endogenous and exogenous substances, which are eliminated from the body via the urine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158314956 ER -