TY - CHAP M1 - Book, Section TI - Inflammatory Bowel Disease A1 - Wilhelm, Sheila M. A1 - McConachie, Sean A2 - Sutton, S. Scott Y1 - 2019 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory condition of the gastrointestinal (GI) tract and consists of ulcerative colitis (UC) and Crohn disease (CD). The incidence of UC in the United States is estimated to be 8 to 12 cases per 100,000 population per year, while CD is reported as approximately 5 cases per 100,000 population per year. While the underlying pathophysiology of IBD involves an abnormal immune inflammatory response directed against the intestinal tract, the true cause of IBD has not been identified. Genetic and environmental factors have been implicated as contributors to the development of IBD. IBD has been observed to occur more commonly in patients who report a positive family history of IBD. Another leading theory is that the inflammatory response is induced by the local bacterial flora that inhabit the human GI tract. Ultimately, the inflammatory response results in injury to the GI tract that may vary in location, depth, severity, and duration. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158315423 ER -