TY - CHAP M1 - Book, Section TI - Cystic Fibrosis A1 - Lubsch, Lisa A2 - Sutton, S. Scott Y1 - 2019 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - Cystic fibrosis (CF) is a life-threatening genetic disease of the epithelial cells in the body, especially those lining the intestinal tract and airways of the lungs. Normally, epithelial cells transport chloride through the cystic fibrosis transmembrane regulator (CFTR) with sodium and water following the ion flux. CF is the loss of the function of the CFTR with defective movement of Cl and water in the body. Thus, the composition of fluid secreted by the pancreas, hepatobiliary tree, reproductive tract, sweat glands, and the airways is thick and leads to obstruction with malfunction. This malfunction eventually leads to widespread organ system disease (Table 47-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158315734 ER -