TY - CHAP M1 - Book, Section TI - Solubility, Dissolution, and Partitioning A1 - Sandmann, Beverly J. A1 - Amiji, Mansoor M. A2 - Mobley, W. Cary A2 - Amiji, Mansoor M. A2 - Cook, Thomas J. Y1 - 2019 N1 - T2 - Applied Physical Pharmacy, 3e AB - Learning ObjectivesAfter completing this chapter, the reader should be able to:Define and understand the terms and concepts of solubility and miscibility.Identify the descriptive terms for solubility, their meaning, and their percent value.Recognize factors that affect solubility.Calculate the solubility of poorly soluble strong electrolytes by using Ksp values.Calculate the solubility of weak electrolytes as a function of pH and understand what the answer means.Calculate the pH of precipitation for weak electrolytes in aqueous and mixed solvent systems.Describe the role of drug dissolution from dosage forms in drug bioavailability.Relate the parameters of the Noyes–Whitney equation to the variables that affect the dissolution rate of drug particles.Recognize and appreciate the United States Pharmacopeia (USP) requirements for dissolution studies.Discuss how various physicochemical, formulation, and physiological factors can influence dissolution behavior.Define and understand the partitioning law, partition coefficients, and apparent partition coefficients.Calculate the partition coefficients for different types of solutes in aqueous/organic solvent systems.Determine the effect of pH on the partition coefficient of weak electrolytes and on their excretion in different body fluids. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1163540490 ER -