TY  - CHAP
M1  - Book, Section
TI  - Fever
A1  - Brown, Jamal
A1  - Kyles, Jenay
A2  - DiPiro, Joseph T.
A2  - Yee, Gary C.
A2  - Posey, L. Michael
A2  - Haines, Stuart T.
A2  - Nolin, Thomas D.
A2  - Ellingrod, Vicki
Y1  - 2020
N1  - 
T2  - Pharmacotherapy: A Pathophysiologic Approach, 11e
AB  - KEY  CONCEPTS  Fever  can  be  a  by-product  of  various  infectious  or  pathologic  processes,  vaccinations,  medications,  and  environmental  exposure,  or  of  vigorous  activity.  Normal  body  temperature  fluctuates  and  is  regulated  in  the  thermoregulatory  center  of  the  anterior  hypothalamus.  During  a  fever,  prostaglandins  cause  an  increase  in  the  hypothalamic  temperature  set  point  and  thereby  increase  production  of  heat  in  the  periphery.  In  a  community  setting,  pharmacists  should  COLLECT  key  information  on  medications,  medical  history,  immunizations,  recent  travel,  social  history,  barriers  of  care,  and  course  of  fever.  Using  the  gathered  data,  pharmacists  should  ASSESS  information  to  differentiate  symptoms  from  surrounding  conditions,  determine  appropriateness  for  self-care,  evaluate  history  for  causes  of  fever,  and  consider  most  appropriate  medication  for  fever.  Goals  of  therapy  include  relieving  discomfort,  reducing  body  temperature,  and  when  appropriate  treating  the  underlying  cause  of  fever.  Nondrug  treatments  include  the  use  of  cooling  blankets,  which  should  only  be  used  along  with  antipyretics.  Appropriate  hydration  and  the  use  of  fans  also  contribute  to  decreasing  body  temperature.  Nonsteroidal  anti-inflammatory  drugs  (NSAIDs)  reduce  fever,  but  they  can  adversely  affect  the  gastrointestinal  tract  and  platelets.  For  this  reason,  acetaminophen  is  the  preferred  agent  to  reduce  fever  in  most  patients.  Therapy  with  NSAIDs  and  acetaminophen  combinations  can  be  used  in  most  but  not  all  patients.  Medical  evaluation  should  be  sought  if  symptoms  of  fever  do  not  resolve  with  over-the-counter  treatment  within  24  hours  in  children  younger  than  2  years,  48  hours  in  other  children  and  3  days  in  adults.  Also,  medical  evaluation  should  occur  in  patients  with  alarming  symptoms  regardless  of  their  temperature.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1182423622
ER  -