TY - CHAP M1 - Book, Section TI - Nanoparticle Toxicology A1 - Warheit, David B. A1 - Oberdörster, Günter A1 - Kane, Agnes B. A1 - Brown, Scott C. A1 - Klaper, Rebecca D. A1 - Hurt, Robert H. A2 - Klaassen, Curtis D. A2 - Watkins, John B. Y1 - 2021 N1 - T2 - Casarett & Doull’s Essentials of Toxicology, 4e AB - KEY POINTSNanotechnology is the understanding and control of matter at nanoscale dimensions between approximately 1 and 100 nm, where unique phenomena enable novel applications.Nanotoxicology can be defined as the study of adverse effects of nanomaterials on living organisms and the environment.Surface properties are major determinants of biological reactivity due to high surface area, surface charge, dissolution and release of metal ions, and redox activity leading to generation of reactive oxygen species (ROS).The respiratory tract is the major route for humans to exposure of nanomaterials.Surface properties are major determinants of biological reactivity due to high surface area, surface charge, hydrophobicity and partitioning into lipid membranes, dissolution and release of metal ions, and redox activity.Dosemetric defines a dose in terms of an inherent property (physical, chemical, reactivity, etc.) SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1178017437 ER -