TY - CHAP M1 - Book, Section TI - Surgical Prophylaxis A1 - Schwinghammer, Terry L. A1 - DiPiro, Joseph T. A1 - Ellingrod, Vicki L. A1 - DiPiro, Cecily V. Y1 - 2021 N1 - T2 - Pharmacotherapy Handbook, 11e AB - Antibiotics administered prior to the contamination of previously sterile tissues or fluids are considered prophylactic. The goal of prophylactic antibiotics is to prevent an infection from developing.Presumptive antibiotic therapy is administered when an infection is suspected but not yet proven. Therapeutic antibiotics are required for established infection.Surgical-site infections (SSIs) are classified as either incisional (eg, cellulitis of the incision site) or involving an organ or space (eg, with meningitis). Incisional SSIs may be superficial (skin or subcutaneous tissue) or deep (fascial and muscle layers). Both types, by definition, occur by postoperative day 30. This period extends to 1 year from the date of surgery in the case of prosthesis implantation involvement with a deep incisional or organ/space infection SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1178897573 ER -