TY  - CHAP
M1  - Book, Section
TI  - Gout
A1  - Bottenberg, Michelle M.
A1  - Bryant, Ginelle
A1  - Butler, Jared
A2  - Sutton, S. Scott
Y1  - 2020
N1  - 
T2  - McGraw Hill’s NAPLEX® Review Guide, 4e
AB  - Gout  is  characterized  by  acute  and  recurrent  arthritis  mediated  by  the  formation  of  monosodium  uric  (MSU)  acid  crystals  within  the  joints  and  surrounding  tissues.  This  results  in  pain,  erythema,  and  inflammation.  Elevated  serum  uric  acid  (SUA)  concentrations  may  predispose  a  patient  to  symptoms  of  gout.  This  elevation  is  traditionally  a  result  of  a  defect  in  purine  metabolism,  a  decrease  in  uric  acid  excretion,  increased  nucleic  acid  turnover,  or  increased  purine  production.  Regardless  of  the  cause,  excessive  intake  of  high  purine  foods  contributes  to  hyperuricemia  and  gout  exacerbations  (Table  48-1).  SUA  concentrations  are  higher  in  obesity,  chronic  kidney  disease,  and  in  patients  who  consume  alcohol.  However,  gout  flares  can  occur  in  individuals  with  normal  SUA  levels  and  elevated  SUA  concentrations  do  not  always  lead  to  the  development  of  gout.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1179735467
ER  -