TY - CHAP M1 - Book, Section TI - Agents That Affect Bone Mineral Homeostasis A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke A1 - Tuan, Rupa Lalchandani A1 - Vanderah, Todd W. A1 - Trevor, Anthony J. Y1 - 2021 N1 - T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 13e AB - Calcium and phosphorus, the two major elements of bone, are crucial not only for the mechanical strength of the skeleton but also for the normal function of many other cells in the body. Three hormones are the main regulators of calcium and phosphate homeostasis, parathyroid hormone (PTH), vitamin D, and fibroblast growth factor 23 (FGF23) (Figure 42–1). Calcitonin, glucocorticoids, and estrogens play secondary roles. These hormones, or drugs that mimic or suppress their actions, are used in the treatment of bone mineral disorders (eg, osteoporosis, rickets, osteomalacia, Paget disease), as are several nonhormonal agents. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1180557708 ER -