TY - CHAP M1 - Book, Section TI - One-Compartment Open Model: Intravenous Bolus Administration A1 - Wight, Kayleigh A1 - Colucci, Philippe A1 - Ducharme, Murray P. A2 - Ducharme, Murray P. A2 - Shargel, Leon Y1 - 2022 N1 - T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Discuss the clinical relevance of IV bolus injection and introduce concepts of the one-compartment linear model with this route of administration.Define volume of distribution, elimination rate constant, and clearance, and explain how to calculate these parameters in a one-compartment linear model with IV bolus injection.Explain the clinical utility of the one-compartment model SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188767807 ER -