TY - CHAP M1 - Book, Section TI - Multicompartment Models: Intravenous Bolus Administration A1 - Sani, Shabnam N. A1 - Siwale, Rodney C. A2 - Ducharme, Murray P. A2 - Shargel, Leon Y1 - 2022 N1 - T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Define the pharmacokinetic terms used in a two- and three-compartment model.Explain using examples why drugs follow one-compartment, two-compartment, or three-compartment kinetics.Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two- and three-compartment model drug.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Explain the consequences of using Vc, Varea (or Vβ), versus Vss to calculate a loading doseEstimate two-compartment model parameters by using the method of residuals.Calculate clearance and alpha and beta half-lives of a two-compartment model drug.Explain how drug metabolic enzymes, transporters, and binding proteins in the body may modify the distribution and/or elimination phase of a drug after IV bolus. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1196299704 ER -