TY  - CHAP
M1  - Book, Section
TI  - Nonlinear Pharmacokinetics
A1  - Shargel, Leon
A1  - Ducharme, Murray P.
A2  - Ducharme, Murray P.
A2  - Shargel, Leon
Y1  - 2022
N1  - 
T2  - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e
AB  - Compare  the  difference  between  linear  pharmacokinetics  and  nonlinear  pharmacokinetics.Explain  why  nonlinear  pharmacokinetics  occurs  with  enzyme  mediated  or  drug  carrier  systems.  Discuss  potential  risks  in  dosing  drugs  that  follow  nonlinear  kinetics.Demonstrate  how  to  detect  nonlinear  kinetics  using  AUC-versus-doses  plots.Use  the  appropriate  equation  and  graphical  methods  to  calculate  the  Vmax  and  KM  parameters  after  multiple  dosing  in  a  patient.Describe  the  use  of  the  Michaelis–Menten  equation  to  simulate  the  elimination  of  a  drug  by  a  saturable  enzymatic  process.Estimate  the  dose  for  a  nonlinear  drug  such  as  phenytoin  in  multiple-dose  regimens.Describe  chronopharmacokinetics  (time-dependent  pharmacokinetics)  and  its  influence  on  drug  disposition.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1188769695
ER  -