TY  - CHAP
M1  - Book, Section
TI  - Relationship between Pharmacokinetics and Pharmacodynamics
A1  - Mathangi, Gopalakrishnan
A1  - Gupta, Vipul Kumar
A1  - Issar, Manish
A2  - Ducharme, Murray P.
A2  - Shargel, Leon
Y1  - 2022
N1  - 
T2  - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e
AB  - Quantitatively  describe  the  relationship  between  drug,  receptor,  and  the  pharmacologic  response.Explain  why  the  intensity  of  the  pharmacologic  response  increases  with  drug  concentrations  and/or  dose  up  to  a  maximum  response.Explain  the  difference  between  an  agonist,  a  partial  agonist,  and  an  antagonist.Describe  the  difference  between  a  reversible  and  a  non-reversible  pharmacologic  response.Define  the  term  biomarker  and  explain  how  biomarkers  can  be  used  in  the  clinical  development  of  drugs.Show  how  the  Emax  and  sigmoidal  Emax  model  describe  the  relationship  of  the  pharmacodynamic  response  to  drug  concentration.Define  the  term  pharmacokinetic–pharmacodynamic  model  and  provide  an  equation  that  quantitatively  simulates  the  time  course  of  drug  action.Explain  the  effect  compartment  in  the  pharmacodynamic  model  and  name  the  underlying  assumptions.Describe  the  effect  of  changing  drug  dose  and/or  drug  elimination  half-life  on  the  duration  of  drug  response.Describe  how  observed  drug  tolerance  or  unusual  hysteresis-type  drug  response  can  be  explained  using  PD  models  based  on  simple  drug  receptor  theory.Define  the  term  drug  exposure  and  explain  how  drug  exposure  relates  to  drug  therapy  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1188770636
ER  -