TY - CHAP M1 - Book, Section TI - Application of Pharmacokinetics to Clinical Situations A1 - Bowers, Dana R. A1 - Tam, Vincent H. A2 - Ducharme, Murray P. A2 - Shargel, Leon Y1 - 2022 N1 - T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Define Medication Therapy Management (MTM) and explain how MTM can improve the success of drug therapy.Explain what “critical-dose drugs” are and name an example.Define therapeutic drug monitoring and explain which drugs should be monitored through a therapeutic drug monitoring service.Calculate a drug dosage regimen in an individual patient for optimal drug therapy for a drug that has complete pharmacokinetic information and for a drug that has incomplete pharmacokinetic information.Explain the relationship of changing the dose and/or the dosing interval on the Cmax(ss), Cmin(ss), and Cav(ss).Define drug–drug interactions and the mechanisms of drug–drug interactions, and provide examples.Define population pharmacokinetics and explain how population pharmacokinetics enables the estimate of pharmacokinetic parameters from relatively sparse data obtained from study subjects. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188770976 ER -