TY - CHAP M1 - Book, Section TI - Application of Pharmacokinetics and Pharmacodynamics to Aging, Obese, and Pediatric Patients A1 - Overholser, Brian R. A1 - Kays, Michael B. A1 - Sowinski, Kevin M. A2 - Ducharme, Murray P. A2 - Shargel, Leon Y1 - 2022 N1 - T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Describe the age-related physiological changes to the gastrointestinal tract in older adults and pediatric patients*.Describe the effects of age on drug absorption in older adults and pediatric patients.Describe the effects of age on drug metabolism and disposition in older adults, pediatric patients, and obese patients.Provide examples of pharmacodynamic changes in older adults and pediatric patients.Describe the pharmacokinetics and pharmacodynamics changes in obese patients.Describe the global prevalence of obesity and the impact of obesity on the health of an individual.Classify obesity based on body mass index.List the classification of the pediatric age categories.Explain the differences in volume distribution in obese versus non-obese patients.Describe the differences in renal elimination between obese and non-obese patients.Apply pharmacokinetic principles for drug dosing in obese patients.Calculate different body weight descriptors and estimate creatinine clearance for obese patients. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188771194 ER -