TY  - CHAP
M1  - Book, Section
TI  - Chapter 18. Toxic Responses of the Heart and Vascular System
A1  - Kang, Y. James
A2  - Klaassen, Curtis D.
A2  - Watkins, John B.
Y1  - 2010
N1  - 
T2  - Casarett & Doull's Essentials of Toxicology, 2e
AB  - Typical  chemical-induced  disturbances  in  cardiac  function  consist  of  effects  on  heart  rate  (chronotropic),  contractility  (inotropic),  conductivity  (dromotropic),  and/or  excitability  (bathmotropic).Any  xenobiotic  that  disrupts  ion  movement  or  homeostasis  may  induce  a  cardiotoxic  reaction  composed  principally  of  disturbances  in  heart  rhythm.All  toxicants  absorbed  into  the  circulatory  system  contact  vascular  cells  before  reaching  other  sites  in  the  body.Common  mechanisms  of  vascular  toxicity  include  (1)  alterations  in  membrane  structure  and  function;  (2)  redox  stress;  (3)  vessel-specific  bioactivation  of  protoxicants;  and  (4)  preferential  accumulation  of  the  active  toxin  in  vascular  cells.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=6483912
ER  -