TY - CHAP M1 - Book, Section TI - Chapter 18. Theophylline A1 - Bauer, Larry A. A2 - Bauer, Larry A. Y1 - 2008 N1 - T2 - Applied Clinical Pharmacokinetics, 2e AB - Theophylline is a methylxanthine compound that is used for the treatment of asthma, chronic obstructive pulmonary disease (COPD; chronic bronchitis and emphysema), and premature apnea. The bronchodilatory effects of theophylline are useful primarily for patients with asthma because bronchospasm is a key component of that disease state.1 The use of theophylline in patients with chronic obstructive pulmonary disease is more controversial because these diseases have different pathophysiologic profiles, although some patients do exhibit a mixed disease profile with a limited reversible airway component. Even COPD patients without significant bronchospasm demonstrate clinical improvement when taking theophylline.2–4 Theophylline is also a central nervous system stimulant which explains its usefulness in the treatment of premature apnea. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=3518338 ER -