TY - CHAP M1 - Book, Section TI - Chapter 44. Cystic Fibrosis A1 - Watson, Holly J. A2 - Sutton, S. Scott Y1 - 2011 N1 - T2 - McGraw-Hill's NAPLEX® Review Guide AB - Cystic fibrosis (CF) is the most common lethal, genetic disease in the white population. CF occurs in about 1 of every 2000 live births in the United States and 5% of the general population are gene carriers.1 CF is a disease of the epithelial cells in the body; especially those lining the intestinal tract and airways of the lungs. Normally, epithelial cells transport chloride through the cystic fibrosis transmembrane regulator (CFTR) with sodium and water following the ion flux. CF is the loss of the function of the CFTR with defective movement of Cl and water in the body. Thus, the composition of fluid secreted by the pancreas, hepatobiliary tree, reproductive tract, sweat glands, and the airways is thick and leads to obstruction with malfunction. This malfunction eventually leads to widespread organ system disease (Table 44-1). SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=7254109 ER -