TY - CHAP M1 - Book, Section TI - Chapter 4. Multicompartment Models: Intravenous Bolus Administration A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. Y1 - 2012 N1 - T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - Pharmacokinetic models are used to simplify all the complex processes that occur during drug administration that include drug distribution and elimination in the body. The model simplification is necessary because of the inability to measure quantitatively all the rate processes in the body, including the lack of access to biological samples from the interior of the body. As described in Chapter 3, pharmacokinetic models are used to simulate drug disposition so dosing regimens for individuals or groups of patients can be calculated. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/20 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56601742 ER -