TY - CHAP M1 - Book, Section TI - Chapter 9. Nonlinear Pharmacokinetics A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. Y1 - 2012 N1 - T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - Previous chapters discussed linear pharmacokinetic models using simple first-order kinetics to describe the course of drug disposition and action. These linear models assumed that the pharmacokinetic parameters for a drug would not change when different doses or multiple doses of a drug were given. With some drugs, increased doses or chronic medication can cause deviations from the linear pharmacokinetic profile previously observed with single low doses of the same drug. This nonlinear pharmacokinetic behavior is also termed dose-dependentpharmacokinetics. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/07 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56602910 ER -