TY - CHAP M1 - Book, Section TI - Chapter 10. Physiologic Drug Distribution and Protein Binding A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. Y1 - 2012 N1 - T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - After a drug is absorbed systemically from the site of administration, the drug molecules are distributed throughout the body by the systemic circulation. The location, extent, and degree of distribution are dependent on the drug's properties and individual patient characteristics such as organ perfusion and blood flow. The drug molecules are carried by the blood to the target site (receptor) for drug action and to other (nonreceptor) tissues as well, where side effects or adverse reactions may occur. These sites may be intra- and/or extracellular. Drug molecules are distributed to eliminating organs, such as the liver and kidney, and to noneliminating tissues, such as the brain, skin, and muscle. In pregnancy, drugs cross the placenta and may affect the developing fetus. Drugs can also be secreted in milk via the mammillary glands, into the saliva and into other secretory pathways. A substantial portion of the drug may be bound to proteins in the plasma and/or in the tissues. Lipophilic drugs deposit in fat, from which the drug may be slowly released. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56603200 ER -