TY  - CHAP
M1  - Book, Section
TI  - Chapter 21. Dose Adjustment in Renal and Hepatic Disease
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
Y1  - 2012
N1  - 
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - Chronic  kidney  disease  (CKD)  is  a  worldwide  public  health  problem  affecting  more  than  50  million  people,  and  more  than  1  million  of  them  are  receiving  kidney  replacement  therapy  (Levey  et  al,  2009).  The  kidney  is  an  important  organ  in  regulating  body  fluids,  electrolyte  balance,  removal  of  metabolic  waste,  and  drug  excretion  from  the  body.  Impairment  or  degeneration  of  kidney  function  affects  the  pharmacokinetics  of  drugs.  Some  of  the  more  common  causes  of  kidney  failure  include  disease,  injury,  and  drug  intoxication.  Table  21-1  lists  some  of  the  conditions  that  may  lead  to  chronic  or  acute  renal  failure.  Acute  diseases  or  trauma  to  the  kidney  can  cause  uremia,  in  which  glomerular  filtration  is  impaired  or  reduced,  leading  to  accumulation  of  excessive  fluid  and  blood  nitrogenous  products  in  the  body.  Uremia  generally  reduces  glomerular  filtration  and/or  active  secretion,  which  leads  to  a  decrease  in  renal  drug  excretion  resulting  in  a  longer  elimination  half-life  of  the  administered  drug.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56607716
ER  -