TY - CHAP M1 - Book, Section TI - Appendix E: Popular Drugs and Pharmacokinetic Parameters A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. Y1 - 2012 N1 - T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - Table Graphic Jump LocationTable E-1 Pharmacokinetic and Pharmacodynamic Parameters for Selected DrugsaView Table||Download (.pdf)Table E-1 Pharmacokinetic and Pharmacodynamic Parameters for Selected DrugsaDrugOral Availability (%)Urinary Excretion (%)Bound in Plasma (%)Clearanceb (mL/min)Volume of Distribution (L)Half-Life (h)Effectivec ConcentrationsToxicc ConcentrationsAcetaminophen88 ± 153 ± 10350 ± 10067 ± 82.0 ± 0.410–20 μg/mL>300 μg/mLAcyclovirAlendrenate15–300.59 (0.58–0.98)75 ± 1015 ± 4330 ± 8048 ± 132.4 ± 0.7 very long (related to bone turnover)Alprazolam88 ± 162071 ± 30.74 ± 0.14 mL/min/kg0.72 ± 0.12 L/Kg12 ± 220–40 ng/mLAlteplase (TPA)—Low—10 ± 4 mL/min/kg0.1 ± 0.01 L/Kg0.08 ± 0.04Amikacin98491 ± 4219 ± 42.3 ± 0.4Amoxicillin93 ± 1086 ± 818180 ± 2815 ± 21.7 ± 0.3Amphotericin B2–5>9032 ± 1453 ± 3618 ± 7Ampicillin62 ± 1782 ± 1018 ± 2270 ± 5020 ± 51.3 ± 0.2Aspirind68 ± 31.4 ± 1.249650 ± 8011 ± 20.25 ± 0.3See salicyclic acidAtenolol56 ± 3094 ± 8709 μg/mLCephalexin90 ± 991 ± 1814 ± 3300 ± 8018 ± 20.90 ± 0.18Cephalothin5271 ± 3470 ± 12018 ± 80.57 ± 0.32Chloramphenicol75–9025 ± 1553 ± 5170 ± 1466 ± 42.7 ± 0.8Chlordiazepoxided1000.7 μg/mLChloroquined89 ± 1661 ± 461 ± 9750 ± 12013,000 ± 46008.9 ± 3.1 days15–30 ng/mL0.25 μg/mLChlorpropamide>9020 ± 1896 ± 12.1 ± 0.46.8 ± 0.833 ± 6Cimetidine62 ± 662 ± 2019540 ± 13070 ± 141.9 ± 0.30.8 μg/mLCiprofloxacin60 ± 1265 ± 1240420 ± 84130 ± 284.1 ± 0.9Clonidine9562 ± 1120210 ± 84150 ± 3012 ± 70.2–2 ng/mLCyclosporine23.7400 ng/mLDiazepamd1009032 ± 1597 ± 13.9 ± 1.338 ± 106.7 ± 1.7 days>10 ng/mL>35 ng/mLDigoxin70 ± 1360 ± 1125 ± 5130 ± 67440 ± 15039 ± 13>0.8 ng/mL>2 ng/mLDiltiazemd44 ± 108 μg/mLErythromycin35 ± 2512 ± 784 ± 3640 ± 29055 ± 311.6 ± 0.7Erythropoietin7.88 mL/min3.70 L/1.73 m24.92Ethambutol77 ± 879 ± 310 μg/mLEthosuximide—25 ± 1500.19 ± 0.04 mL/min/kg0.72 ± 0.16 L/kg45 ± 840–100 μg/mLFamciclovir77 ± 874 ± 960901 μg/mLIndinavir˜3Indomethacin9815 ± 890140 ± 3018 ± 52.4 ± 0.40.3–3 μg/mL>5 μg/mLLabetalol18 ± 5<5501750 ± 700660 ± 2404.9 ± 2.00.13 μg/mLLidocaine35 ± 112 ± ... SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/08 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56609197 ER -