TY - CHAP M1 - Book, Section TI - Intrathecal Injections A1 - Barthol, Colleen A1 - Gamboa, Conrado A2 - Attridge, Rebecca L. A2 - Miller, Monica L. A2 - Moote, Rebecca A2 - Ryan, Laurajo Y1 - 2013 N1 - T2 - Internal Medicine: A Guide to Clinical Therapeutics AB - Table Graphic Jump LocationTable C-1 Adult Intrathecal Analgesic Injections*View Table||Download (.pdf)Table C-1 Adult Intrathecal Analgesic Injections*ClassMedicationUsual DoseOnsetDurationConcentrationSide EffectsOpioid AnalgesicsFentanyl5–25mcg/dose5–10min1–4h0.05mg/mL PFSedation, N/V, urinary retention, respiratory depression, constipationHydromorphone50–100mcg/dose††10mg/mL PFSedation, N/V, pruritus, urinary retention, respiratory depression, constipationMorphine0.2–1mg/dose (APS recommends 0.1–0.3mg/dose)45–75min18–24h0.5, 1, 10, 25mg/mL PFSedation, N/V, pruritus, urinary retention, respiratory depression, constipationSedativesMidazolam1–2mg/dose5–10min2–4h1, 5mg/mL PF (diluted to max conc 1mg/mL)Sedation, motor weakness, respiratory depressionNonopioid AdjuvantsBaclofen25–75mcg/dose30–60min4–8h0.05, 0.5, 2mg/mL PFSedation, cognitive impairment, weakness, hypotension, constipation, urinary retentionClonidine25–75mcg30–60min6–8h100, 500mcg/mL PFOrthostatic hypotension, bradycardia, sedation SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=57296236 ER -