TY - CHAP M1 - Book, Section TI - Chemical Carcinogenesis A1 - Klaunig, James E. Y1 - 2012 N1 - T2 - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e AB - OverviewHistorical BackgroundDefinitionsMultistage CarcinogenesisInitiationPromotionProgressionMechanisms of Action of Chemical CarcinogensGenotoxic/DNA-Reactive CompoundsDirect-Acting (Activation-Independent) CarcinogensIndirect-Acting Genotoxic CarcinogensMutagenesisDamage by Alkylating ElectrophilesDNA RepairDNA Repair MechanismsMismatch Repair of Single-Base MispairsExcision RepairEnd-Joining Repair of Nonhomologous DNAClasses of Genotoxic CarcinogensPolyaromatic HydrocarbonsAlkylating AgentsAromatic Amines and AmidesClasses and Mode of Action of Nongenotoxic (Epigenetic) CarcinogensCytotoxicityα2u-Globulin-Binding DrugsReceptor-MediatedHormonal Mode of ActionDNA Methylation and CarcinogenesisOxidative Stress and Chemical CarcinogenesisOxidative DNA Damage and CarcinogenesisOxidative Stress and Cell Growth RegulationGap Junctional Intercellular Communication and CarcinogenesisInorganic CarcinogensMetalsModifiers of Chemical Carcinogenic EffectsPolymorphisms in Carcinogen Metabolism and DNA RepairProto-Oncogenes and Tumor-Suppressor GenesRetrovirusesDNA VirusesProto-OncogenesTumor-Suppressor GenesHormesis, Dose Response, and CarcinogenesisChemopreventionAssessing Carcinogenicity of ChemicalsShort-Term Tests for MutagenicityIn Vitro Gene Mutation AssaysIn Vivo Gene Mutation AssaysChromosomal AlterationsDNA DamageShort-Term Tests: Transformation AssaysChronic Testing for CarcinogenicityChronic (Two Year) BioassayOrgan-Specific Bioassays and Multistage Animal ModelsTransgenic Animals in Carcinogenicity AssessmentNew ApproachesChemical Carcinogenesis in HumansClassification Evaluation of Carcinogenicity in HumansSummary SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1100086393 ER -