TY - CHAP M1 - Book, Section TI - Toxic Responses of the Heart and Vascular System A1 - Kang, Y. James Y1 - 2012 N1 - T2 - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e AB - IntroductionOverview of the HeartOverview of Cardiac Structural and Physiological FeaturesReview of Cardiac StructureElectrophysiologyContractilityElectrotonic Cell-to-Cell CouplingElectrocardiographNeurohormonal RegulationOverview of Cardiac Energy Metabolism and BiochemistryATP and the HeartPhosphocreatine and the HeartMetabolic PathwaysCalcium and CalcineurinAMP-Activated Protein KinaseMitogen-Activated Protein KinasesProtein Kinase CTranscription FactorsCardiac Toxic ResponsesBasic Concepts and DefinitionsCardiac ArrhythmiaCardiac HypertrophyHeart FailureAcute Cardiac ToxicityChronic Cardiac ToxicityMyocardial Degeneration and RegenerationMyocardial Degenerative ResponsesToxic Effect on Myocardial RegenerationReversible and Irreversible Toxic ResponsesMyocardial Cell Death and Signaling PathwaysApoptosis and NecrosisMitochondrial Control of Cell DeathDeath Receptors and Signaling PathwaysMitochondrial Dynamics and AutophagyMitochondrial DynamicsAutophagyCardiac Hypertrophy and Heart FailureAdaptive and Maladaptive ResponsesHypertrophic Signaling PathwaysTransition from Cardiac Hypertrophy to Heart FailureQT Prolongation and Sudden Cardiac DeathDefinition of QT ProlongationMolecular Basis of QT ProlongationTorsade De Pointes and Sudden Cardiac DeathParameters Affecting QT Prolongation and Torsadogen-esisBiomarkers for Cardiac ToxicityValidation of BiomarkersAvailability of BiomarkersBiomarker Applications and LimitationsCardiac Toxic ChemicalsAlcohol and Alcoholic CardiomyopathyPharmaceutical ChemicalsAntiarrhythmic AgentsInotropic DrugsCentral Nervous System Acting DrugsLocal AnestheticsAnthracyclines and Other Antineoplastic AgentsAntimicrobial and Antiviral AgentsAnti-Inflammatory AgentsAntihistaminesImmunosuppressantsMiscellaneous DrugsNatural ProductsCatecholaminesSteroids and Related HormonesCytokinesAnimal and Plant ToxinsEnvironmental Pollutants and Industrial ChemicalsParticulate MattersSolventsAlcohols and AldehydesHalogenated AlkanesMetals and MetalloidsOverview of Vascular SystemVascular Physiology and Structural FeaturesArterial System and Physiological FunctionCapillaries and MicrocirculationVenous System and Physiological FunctionLymphatic System and Physiological FunctionRegulatory Mechanisms of the Vascular SystemNeurohormonal RegulationLocal Metabolic RegulationVascular System Toxic ResponsesMechanisms of Vascular ToxicityResponses of Vascular Endothelial Cells to Toxic InsultsResponses of Smooth Muscle Cells to Toxic InsultsOxidative Stress and Vascular InjuryInflammatory LesionsToxic Responses of Blood VesselsHypertension and HypotensionAtherosclerosisHemorrhageEdemaVascular System Toxic ChemicalsPharmaceutical ChemicalsSympathomimetic AminesNicotineCocainePsychotropic AgentsAntineoplastic AgentsAnalgesics and Nonsteroidal Anti-Inflammatory AgentsOral ContraceptivesNatural ProductsBacterial EndotoxinsHomocysteineHydrazinobenzoic AcidT-2 ToxinVitamin Dβ-AmyloidEnvironmental Pollutants and Industrial ChemicalsCarbon MonoxideCarbon Disulfide1,3-ButadieneMetals and MetalloidsAromatic HydrocarbonsParticulate Air Pollution SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1100088753 ER -