TY  - CHAP
M1  - Book, Section
TI  - Epigraph
A1  - Hoffman, Robert S.
A1  - Howland, Mary Ann
A1  - Lewin, Neal A.
A1  - Nelson, Lewis S.
A1  - Goldfrank, Lewis R.
Y1  - 2015
N1  - 
T2  - Goldfrank's Toxicologic Emergencies, 10e
AB  - Erythroxylum  coca,  the  source  of  cocaine,  is  renowned  in  toxicology  and  medicine  for  its  ritual  use  by  ancient  cultures,  traditional  use  by  modern  indigenous  peoples,  role  as  the  first  pharmaceutical  local  anesthetic,  and  notorious  use  as  an  illicit  drug  of  abuse.  The  molecule  benzoylmethylecgonine  (cocaine)  highlights  the  complex  structure  of  a  plant  alkaloid.  At  the  cellular  level,  cocaine  is  a  remarkable  drug  that  blocks  the  reuptake  of  neurotransmitters  (dopamine,  norepinephrine,  epinephrine,  and  serotonin),  blocks  neuronal  and  cardiac  sodium  channels,  and  causes  vasoconstriction.  The  cardiotoxic  effects  are  demonstrated  on  the  electrocardiogram,  which  shows  a  classic  ST  segment  anterior  wall  myocardial  infarction  in  a  young  person  who  recently  used  cocaine.  Although  a  true  antidote  to  cocaine  toxicity  has  yet  to  be  developed,  the  vial  represents  the  benzodiazepines,  which  have  become  the  mainstay  of  therapy  for  psychomotor  agitation  that  results  from  typical  cocaine  overdose.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1103621962
ER  -