TY - CHAP M1 - Book, Section TI - Antidotes in Depth A1 - Smith, Silas W. A1 - Howland, Mary Ann A2 - Hoffman, Robert S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Nelson, Lewis S. A2 - Goldfrank, Lewis R. Y1 - 2015 N1 - T2 - Goldfrank's Toxicologic Emergencies, 10e AB - Activated charcoal (AC) is an excellent nonspecific adsorbent. Understanding AC's role in poison management is established by the integration of pharmacologic data, controlled volunteer trials, studies in heterogeneous patients with overdose or poisoning, and clinical experience.24 AC should be considered for a poisoned or overdosed patient after a risk-to-benefit assessment of the presumed ingested substance and patient-specific factors and circumstances.11 Benefits include preventing absorption or enterohepatic recirculation of a potentially toxic xenobiotic; risks include vomiting and subsequent aspiration pneumonitis. A detailed discussion of the merits of AC as a decontamination strategy is presented in Chap. 8. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1108421280 ER -