TY - CHAP M1 - Book, Section TI - From Applied Clinical Pharmacokinetics, First Edition A1 - Bauer, Larry A. Y1 - 2015 N1 - T2 - Applied Clinical Pharmacokinetics, 3e AB - The structure of this book is uniform for each chapter and is derived from my lectures in clinical pharmacokinetics. The introduction, which consists of a brief discussion of the clinical pharmacology and mechanism of action for the drug, is followed by sections that describe the therapeutic concentration range and anticipated adverse effects for the drug as well as a general monitoring scheme for the agent. Clinical monitoring parameters for therapeutic response and toxicity and basic clinical pharmacokinetic parameters for the compound are discussed next. The next sections describe the effects of disease states and conditions on the pharmacokinetics and dosing of the drug, and drug interactions that may occur with concurrent use of other agents. Each chapter concludes with a comprehensive presentation (with examples) of various methods to compute initial drug doses and to modify drug therapy regimens using serum concentrations to adjust doses. All dosing methods used in this text are ones that are published in peer-reviewed literature. Additionally, they are techniques that I have personal clinical experience with and have produced acceptable results in my practice and clinical clerkships. Finally, problems (with solutions) are included for each chapter so that the various dosing methods can be practiced. The problems are made up of brief clinical vignettes which, given a brief background, request that initial doses be computed or that dosage regimens be modified using drug concentrations. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/10/08 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1106302400 ER -