TY  - CHAP
M1  - Book, Section
TI  - Lamotrigine
A1  - Bauer, Larry A.
Y1  - 2015
N1  - 
T2  - Applied Clinical Pharmacokinetics, 3e
AB  - Lamotrigine  is  a  phenyltriazine-based  compound  effective  in  the  treatment  of  partial  and  generalized  seizures  (Table  15-1).1,2,3,  and  4  Although  lamotrigine  is  listed  as  a  recommended  therapy  for  absence  seizures  by  expert  panels,  recent  literature  suggests  that  ethosuximide  or  valproic  acid  may  be  more  effective  initial  therapy  for  this  epilepsy  type.5,6  It  is  also  useful  for  the  treatment  of  bipolar  disorders,  neurogenic  pain,  and  Lennox-Gastaut  syndrome.7,8,  and  9  While  lamotrigine  was  originally  developed  as  a  antifolate  agent,  its  therapeutic  effects  are  not  related  to  this  property.  The  proposed  mechanism  of  action  in  humans  is  the  inhibition  of  voltage-sensitive  sodium  channels,  which  stabilizes  neuronal  membranes  and  modulates  the  presynaptic  transmitter  release  of  glutamate  and  aspartate.9,10,11,  and  12  
SN  - 
PB  - McGraw-Hill Medical
CY  - New York, NY
Y2  - 2024/04/20
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1106304021
ER  -