TY  - CHAP
M1  - Book, Section
TI  - Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
A1  - Young, Neal S.
A2  - Kasper, Dennis
A2  - Fauci, Anthony
A2  - Hauser, Stephen
A2  - Longo, Dan
A2  - Jameson, J. Larry
A2  - Loscalzo, Joseph
Y1  - 2014
N1  - 
T2  - Harrison's Principles of Internal Medicine, 19e
AB  - The  hypoproliferative  anemias  are  normochromic,  normocytic,  or  macrocytic  and  are  characterized  by  a  low  reticulocyte  count.  Hypoproliferative  anemia  is  also  a  prominent  feature  of  hematologic  diseases  that  are  described  as  bone  marrow  failure  states;  these  include  aplastic  anemia,  myelodysplastic  syndrome  (MDS),  pure  red  cell  aplasia  (PRCA),  and  myelophthisis.  Anemia  in  these  disorders  is  often  not  a  solitary  or  even  the  major  hematologic  finding.  More  frequent  in  bone  marrow  failure  is  pancytopenia:  anemia,  leukopenia,  and  thrombocytopenia.  Low  blood  counts  in  the  marrow  failure  diseases  result  from  deficient  hematopoiesis,  as  distinguished  from  blood  count  depression  due  to  peripheral  destruction  of  red  cells  (hemolytic  anemias),  platelets  (idiopathic  thrombocytopenic  purpura  [ITP]  or  due  to  splenomegaly),  and  granulocytes  (as  in  the  immune  leukopenias).  Marrow  damage  and  dysfunction  also  may  be  secondary  to  infection,  inflammation,  or  cancer.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2022/05/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1120794171
ER  -