TY - CHAP M1 - Book, Section TI - Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia A1 - Young, Neal S. A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph Y1 - 2014 N1 - T2 - Harrison's Principles of Internal Medicine, 19e AB - The hypoproliferative anemias are normochromic, normocytic, or macrocytic and are characterized by a low reticulocyte count. Hypoproliferative anemia is also a prominent feature of hematologic diseases that are described as bone marrow failure states; these include aplastic anemia, myelodysplastic syndrome (MDS), pure red cell aplasia (PRCA), and myelophthisis. Anemia in these disorders is often not a solitary or even the major hematologic finding. More frequent in bone marrow failure is pancytopenia: anemia, leukopenia, and thrombocytopenia. Low blood counts in the marrow failure diseases result from deficient hematopoiesis, as distinguished from blood count depression due to peripheral destruction of red cells (hemolytic anemias), platelets (idiopathic thrombocytopenic purpura [ITP] or due to splenomegaly), and granulocytes (as in the immune leukopenias). Marrow damage and dysfunction also may be secondary to infection, inflammation, or cancer. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2022/05/24 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1120794171 ER -