TY - CHAP M1 - Book, Section TI - Tularemia A1 - Jacobs, Richard F. A1 - Schutze, Gordon E. A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph Y1 - 2014 N1 - T2 - Harrison's Principles of Internal Medicine, 19e AB - Tularemia is a zoonosis caused by Francisella tularensis. Humans of any age, sex, or race are universally susceptible to this systemic infection. Tularemia is primarily a disease of wild animals and persists in contaminated environments, ectoparasites, and animal carriers. Human infection is incidental and usually results from interaction with biting or blood-sucking insects, contact with wild or domestic animals, ingestion of contaminated water or food, or inhalation of infective aerosols. The illness is characterized by various clinical syndromes, the most common of which consists of an ulcerative lesion at the site of inoculation, with regional lymphadenopathy and lymphadenitis. Systemic manifestations, including pneumonia, typhoidal tularemia, meningitis, and fever without localizing findings, pose a greater diagnostic challenge. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2022/06/25 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1120799236 ER -