TY - CHAP M1 - Book, Section TI - Menopause and Postmenopausal Hormone Therapy A1 - Manson, JoAnn E. A1 - Bassuk, Shari S. A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph Y1 - 2014 N1 - T2 - Harrison's Principles of Internal Medicine, 19e AB - Menopause is the permanent cessation of menstruation due to loss of ovarian follicular function. It is diagnosed retrospectively after 12 months of amenorrhea. The average age at menopause is 51 years among U.S. women. Perimenopause refers to the time period preceding menopause, when fertility wanes and menstrual cycle irregularity increases, until the first year after cessation of menses. The onset of perimenopause precedes the final menses by 2–8 years, with a mean duration of 4 years. Smoking accelerates the menopausal transition by 2 years. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2021/03/05 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1120815854 ER -