TY - CHAP M1 - Book, Section TI - Pharmacology Basics A1 - Pelletier-Dattu, Catherine E. Y1 - 2017 N1 - T2 - Lange Smart Charts: Pharmacology, 2e AB - Table Graphic Jump Location|Download (.pdf)|PrintAgonistA drug that activates its receptor upon binding.BioavailabilityThe percentage of administered dose that reaches the systemic circulation.Chemical AntagonistA drug that counters the effects of another by binding the drug and preventing its action.Competitive AntagonistA pharmacologic antagonist that can be overcome by increasing the dose of agonist.EC50In graded dose-response curves, the concentration or dose that produces 50% of the maximum possible response; in quantal dose-response curves, the dose that causes the specified response in 50% of the population.ED50Dose required to produce the desired effect in 50% of subjects.EffectorComponent of the biologic system that accomplishes the biologic effect after being activated by the receptor; often a channel or enzyme.EfficacyThe maximum effect a drug can bring about, regardless of dose.Graded Dose-Response CurveA graph of the increasing responses to increasing doses of a drug.Inert Binding SiteA component of the biologic system to which a drug binds without changing any function.Irreversible AntagonistA pharmacologic antagonist that cannot be overcome by increasing the dose of the agonist.KdThe concentration of drug that results in binding to 50% of the receptors.LD50Dose that is lethal to 50% of subjects.Partial AgonistA drug that binds to its receptor but produces a smaller effect at full dosage than a full agonist.pHInverse log of the hydrogen ion concentration, denotes the acidity or alkalinity of a substance.PharmacodynamicsThe actions of the drug on the body.PharmacokineticsThe action of the body on the drug.Pharmacologic AntagonistA drug that binds to its receptor without activating it.PharmacologyThe study of substances that interact with living systems through chemical reactions.Physiologic AntagonistA drug that counters the effects of another by binding to a different receptor and causing opposing effects.pKaInverse log of the ionization constant of an acid.PotencyThe dose or concentration required to bring about 50% of a drug's maximal effect.Quantal Dose-Response CurveA graph of the fraction of a population that shows a specified response to increasing doses of a drug.ReceptorA component of the biologic system to which a drug binds to bring about a change in function of the system.Receptor SiteThe specific region of the receptor molecule at which the drug binds.Spare ReceptorsReceptors that do not have to bind drug in order for the maximum effect to be produced; ie, Kd greater than the EC50; thought to exist if the maximal response is obtained at less than maximal receptor occupation levels.TI50Drug dose that indicates the ratio of desired to undesired effects. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1114602049 ER -