TY - CHAP
M1 - Book, Section
TI - One-Compartment Open Model: Intravenous Bolus Administration
A1 - Lee, David S.H.
A2 - Shargel, Leon
A2 - Yu, Andrew B.C.
PY - 2016
T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB - Describe a one-compartment model, IV bolus injection.Provide the pharmacokinetic terms that describe a one-compartment model, IV bolus injection, and the underlying assumptions.Explain how drugs follow one-compartment kinetics using drug examples that follow one-compartment kinetics.Calculate pharmacokinetic parameters from drug concentrationâ€“time data using a one-compartment model.Simulate one-compartment plasma drug level graphically using the one-compartment model equation.Calculate the IV bolus dose of a drug using the one-compartment model equation.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Derive model parameters from slope and intercept of the appropriate graphs.
SN -
PB - McGraw-Hill Education
CY - New York, NY
Y2 - 2021/11/30
UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117896709
ER -