TY  - CHAP
M1  - Book, Section
TI  - One-Compartment Open Model: Intravenous Bolus Administration
A1  - Lee, David S.H.
A2  - Shargel, Leon
A2  - Yu, Andrew B.C.
PY  - 2016
T2  - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB  - Describe  a  one-compartment  model,  IV  bolus  injection.Provide  the  pharmacokinetic  terms  that  describe  a  one-compartment  model,  IV  bolus  injection,  and  the  underlying  assumptions.Explain  how  drugs  follow  one-compartment  kinetics  using  drug  examples  that  follow  one-compartment  kinetics.Calculate  pharmacokinetic  parameters  from  drug  concentration–time  data  using  a  one-compartment  model.Simulate  one-compartment  plasma  drug  level  graphically  using  the  one-compartment  model  equation.Calculate  the  IV  bolus  dose  of  a  drug  using  the  one-compartment  model  equation.Relate  the  relevance  of  the  magnitude  of  the  volume  of  distribution  and  clearance  of  various  drugs  to  underlying  processes  in  the  body.Derive  model  parameters  from  slope  and  intercept  of  the  appropriate  graphs.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1117896709
ER  -