TY  - CHAP
M1  - Book, Section
TI  - Multicompartment Models: Intravenous Bolus Administration
A1  - Sani, Shabnam N.
A1  - Siwale, Rodney C.
A2  - Shargel, Leon
A2  - Yu, Andrew B.C.
PY  - 2016
T2  - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB  - Define  the  pharmacokinetic  terms  used  in  a  two-  and  three-compartment  model.Explain  using  examples  why  drugs  follow  one-compartment,  two-compartment,  or  three-compartment  kinetics.Use  equations  and  graph  to  simulate  plasma  drug  concentration  at  various  time  periods  after  an  IV  bolus  injection  of  a  drug  that  follows  the  pharmacokinetics  of  a  two-  and  three-compartment  model  drug.Relate  the  relevance  of  the  magnitude  of  the  volume  of  distribution  and  clearance  of  various  drugs  to  underlying  processes  in  the  body.Estimate  two-compartment  model  parameters  by  using  the  method  of  residuals.Calculate  clearance  and  alpha  and  beta  half-lives  of  a  two-compartment  model  drug.Explain  how  drug  metabolic  enzymes,  transportors,  and  binding  proteins  in  the  body  may  modify  the  distribution  and/or  elimination  phase  of  a  drug  after  IV  bolus.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1117897047
ER  -