TY - CHAP
M1 - Book, Section
TI - Multicompartment Models: Intravenous Bolus Administration
A1 - Sani, Shabnam N.
A1 - Siwale, Rodney C.
A2 - Shargel, Leon
A2 - Yu, Andrew B.C.
PY - 2016
T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB - Define the pharmacokinetic terms used in a two- and three-compartment model.Explain using examples why drugs follow one-compartment, two-compartment, or three-compartment kinetics.Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two- and three-compartment model drug.Relate the relevance of the magnitude of the volume of distribution and clearance of various drugs to underlying processes in the body.Estimate two-compartment model parameters by using the method of residuals.Calculate clearance and alpha and beta half-lives of a two-compartment model drug.Explain how drug metabolic enzymes, transportors, and binding proteins in the body may modify the distribution and/or elimination phase of a drug after IV bolus.
SN -
PB - McGraw-Hill Education
CY - New York, NY
Y2 - 2020/05/26
UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117897047
ER -