TY - CHAP M1 - Book, Section TI - Lipids: Lipolysis, Fatty Acid Oxidation, and Ketogenesis A1 - King, Michael W. PY - 2014 T2 - Integrative Medical Biochemistry Examination and Board Review AB - High-Yield TermsAdipose tissue triglyceride lipase (ATGL): primary rate-limiting enzyme involved in adipose tissue triglyceride metabolismHormone-sensitive lipase (HSL): an adipose tissue–specific hydrolase responsible for the release of fatty acids from stored triglycerides. Its activity is regulated by hormone-mediated phosphorylationα-oxidation: peroxisomal oxidation pathway responsible for the oxidation of the methyl-substituted fatty acid, phytanic acid present at high concentration in the tissues of ruminantsβ-oxidation: major pathway for oxidation of fatty acids in both the mitochondria and the peroxisomes; peroxisomal β-oxidation is also important for metabolism of dicarboxylic acids generated via the ω-oxidation pathwayω-oxidation: a minor, but clinically significant, pathway for fatty oxidation initiated by microsomal ω-hydroxylation reactions, also involves the oxidation of dicarboxylic acids generatedKetone body: any of the compounds, β-hydroxybutyrate, acetoacetate, and acetone, generated during hepatic ketogenesis from the substrate, acetyl-CoADiabetic ketoacidosis (DKA): a condition of increased plasma ketone body concentration caused by excess adipose tissue fatty acid release and hepatic fatty acid oxidation resulting from unregulated glucagon release SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1122104045 ER -