TY - CHAP M1 - Book, Section TI - Lipids: Cholesterol Metabolism A1 - King, Michael W. PY - 2014 T2 - Integrative Medical Biochemistry Examination and Board Review AB - High-Yield TermsCholesterol ester: product of fatty acid esterification of the 3-OH catalyzed by ACAT or LCATReverse cholesterol transport: process by which cholesterol is transferred from nonhepatic cells to HDLs and then transported back to the liver via bloodLDL: low-density lipoprotein, derived from de novo VLDL synthesized in the liver, referred to as “bad cholesterol”HDL: lipoprotein particle involved in reverse cholesterol transport, referred to as “good cholesterol”SREBP2: sterol-regulated element-binding protein 2, controls the expression of genes involved in hepatic cholesterol biosynthesisSCAP: SREBP cleavage-activating protein, cleaves the transcription factor domain from ER-embedded SREBP, allowing it to migrate to the nucleusInsig: insulin-regulated gene, regulates the activity of SCAPIsoprenoid: any compound containing the 5-carbon organic molecule isoprene (also called terpene) with the formula: CH2=C−(CH3)−CH=CH2Prenylation: process of attaching isoprenoid intermediates of the cholesterol biosynthetic pathway (farnesyl pyrophosphate and geranylgeranyl pyrophosphate) to proteins SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1122104110 ER -