TY  - CHAP
M1  - Book, Section
TI  - Membrane Transporters and Drug Response
A1  - Hilal-Dandan, Randa
A1  - Brunton, Laurence L.
PY  - 2016
T2  - Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
AB  - Transporters  are  membrane  proteins  that  are  present  in  all  organisms.  These  proteins  control  the  influx  of  essential  nutrients  and  ions  and  the  efflux  of  cellular  waste,  environmental  toxins,  drugs,  and  other  xenobiotics  (Figure  5–1),  consistent  with  their  critical  roles  in  cellular  homeostasis,  ~2000  genes  in  the  human  genome,  ~7%  of  the  total  number  of  genes,  code  for  transporters  or  transporter-related  proteins.  The  functions  of  membrane  transporters  may  be  facilitated  (equilibrative,  not  requiring  energy)  or  active  (requiring  energy).  In  considering  the  transport  of  drugs,  pharmacologists  generally  focus  on  transporters  from  2  major  superfamilies,  ABC  (ATP  binding  cassette)  and  SLC  (solute  carrier)  transporters.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1127547559
ER  -