TY - CHAP M1 - Book, Section TI - Epilepsy A1 - Nguyen, Viet-Huong V. A1 - Baca, Christine B. A1 - Chen, Jack J. A1 - Rogers, Susan J. A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateJan. 10, 2018Newly Approved Medications for Lennox-Gastaut and Dravet Syndromes: The U.S. FDA approved two new medications for additional seizure control in patients who are resistant to standard therapies alone. Cannabidiol (Epidiolex) was approved as an adjunctive treatment for seizures related to Dravet and Lennox-Gastaut Syndromes and stiripentol (Diacomit) is indicated for patients with Dravet Syndrome who are also taking clobazam. Both medications have proven to be effective in decreasing the percentage of drop seizures over a trial period compared to placebo. Though these medications appear effective, the true long-term impact cannot be accurately assessed with the data presented. Both of these drugs will be available in the United States over the course of 2019. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1161501483 ER -