TY - CHAP M1 - Book, Section TI - Headache Disorders A1 - Minor, Deborah S. A1 - Harrell, T. Kristopher A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateNovember 15, 2019Newly Approved Medications for Migraines: The U.S. FDA approved three new medications with novel mechanism of action for migraine prophylaxis. The calcitonin gene-related peptide (CGRP) antagonists, erenumab (Aimovig®), fremanezumab (Ajovy®), and galcanezumab (Emgality®) were approved in 2018 for migraine prophylaxis.The CGRP antagonist therapies were approved for migraine prophylaxis in adults because of its hypothesized role in mediating trigeminovascular pain transmission and vasodilation activity for neurogenic inflammation. Although these medications appear effective, more data are needed regarding their long-term safety as well as use in special populations. All three therapies are available in the United States. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1167761712 ER -