TY - CHAP M1 - Book, Section TI - Drugs Used in Dementia A1 - Stringer, Janet L. PY - 2017 T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e AB - Dementia, including Alzheimer disease, has been found to involve a number of systems in the brain. There is evidence for a decrease in markers of cholinergic neuron activity and for changes in brain glutamate, dopamine, norepinephrine, serotonin, and somatostatin. Eventually, cholinergic neurons die or are destroyed. Treatment has focused on increasing the amount of acetylcholine in the synapse by inhibiting the breakdown of acetylcholine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1142821069 ER -