TY  - CHAP
M1  - Book, Section
TI  - Hypothalamic & Pituitary Hormones
A1  - Long, Roger K.
A1  - Cakmak, Hakan
A2  - Katzung, Bertram G.
PY  - 2017
T2  - Basic & Clinical Pharmacology, 14e
AB  - CASE  STUDYA  4-year-old  boy  (height  90  cm,  –3  standard  deviations  [SD];  weight  14.5  kg,  approximately  15th  percentile)  presents  with  short  stature.  Review  of  the  past  history  and  growth  chart  demonstrates  normal  birth  weight  and  birth  length,  but  a  progressive  decrease  in  height  percentiles  relative  to  age-matched  normal  ranges  starting  at  6  months  of  age,  and  orthostasis  with  febrile  illnesses.  Physical  examination  demonstrates  short  stature  and  mild  generalized  obesity.  Genital  examination  reveals  descended  but  small  testes  and  a  phallic  length  of  –2  SD.  Laboratory  evaluations  demonstrate  growth  hormone  (GH)  deficiency  and  a  delayed  bone  age  of  18  months.  The  patient  is  started  on  replacement  with  recombinant  human  GH  at  a  dose  of  40  mcg/kg  per  day  subcutaneously.  After  1  year  of  treatment,  his  height  velocity  has  increased  from  5  cm/y  to  11  cm/y.  How  does  GH  stimulate  growth  in  children?  What  other  hormone  deficiencies  are  suggested  by  the  patient’s  history  and  physical  examination?  What  other  hormone  replacements  is  this  patient  likely  to  require?  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1148438684
ER  -