TY - CHAP M1 - Book, Section TI - The Biochemistry of Aging A1 - Kennelly, Peter J. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Describe the essential features of wear and tear theories of aging.List four or more common environmental constituents known to damage biologic macromolecules such as proteins and DNA.Explain why nucleotide bases are especially vulnerable to damage.Describe the most physiologically important difference between mitochondrial and nuclear genomes.Describe the oxidative theory of aging.List the primary sources of reactive oxygen species (ROS) in humans.Describe three mechanisms by which cells prevent or repair damage inflicted by ROS.Describe the basic tenets of metabolic theories of aging.Explain the mechanism of the telomere “countdown clock.”Outline our current understanding of the genetic contribution to aging.Explain the benefits of model organisms to biomedical research. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1160193930 ER -