TY  - CHAP
M1  - Book, Section
TI  - The Role of Circadian Biology in Health and Disease
A1  - Cedernaes, Jonathan
A1  - Ramsey, Kathryn Moynihan
A1  - Bass, Joseph
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Circadian  rhythms  are  autonomous,  systemic  cycles  of  behavior  and  physiology  that  synchronize  organismal  function  at  the  cell  and  tissue  level  in  anticipation  of  the  24-h  rotation  of  the  Earth.  A  common  feature  of  modern  “24/7”  life  is  the  routine  disruption  in  these  evolutionarily  conserved  endogenous  circadian  cycles,  due  to  the  rise  in  shift  work,  jet  travel  across  time  zones,  exposure  to  blue  light–emitting  devices  at  night,  and  disrupted  sleep.  A  transformation  in  understanding  the  molecular  basis  of  circadian  disorders  has  generated  a  new  wave  of  research  on  metabolic  disease,  inflammation,  aging,  and  cancer.  This  chapter  provides  an  overview  of  (1)  the  basic  biology  of  the  circadian  system;  (2)  primary  circadian  rhythm  and  interrelated  sleep  disorders;  and  (3)  the  role  of  the  circadian  system  in  both  normal  human  physiology  and  disease  states.  Lastly,  we  review  the  rapidly  emerging  field  of  chronobiology  as  a  pathway  for  novel  diagnostic  and  therapeutic  activity.  A  glossary  of  terms  used  in  circadian  biology  is  summarized  in  Table  475-1.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1156522115
ER  -