TY - CHAP M1 - Book, Section TI - Disorders of the Immune System A1 - Kishiyama, Jeffrey L. A1 - Chang, Jennifer J. A1 - Donovan, Suzanne M. A2 - Hammer, Gary D. A2 - McPhee, Stephen J. PY - 2019 T2 - Pathophysiology of Disease: An Introduction to Clinical Medicine, 8e AB - The function of the immune system is to protect the host from invasion of foreign organisms by distinguishing “self” from “non-self.” A well-functioning immune system not only protects the host from external factors such as microorganisms or toxins but also prevents and repels attacks by endogenous factors such as tumors and participates in tissue repair. A normal immune response relies on the careful coordination of a complex network of biological factors, specialized cells, tissues, and organs necessary for the recognition of pathogens and subsequent elimination of foreign antigens. Dysfunction or deficiency of components of the immune system leads to a variety of clinical diseases of varying expression and severity, ranging from atopic disease to autoimmune disease, primary immunodeficiency, and cancer. This chapter introduces the intricate physiology of the immune system and abnormalities that lead to diseases of hypersensitivity and immunodeficiency. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1156655889 ER -