TY - CHAP M1 - Book, Section TI - Methylene Blue A1 - Howland, Mary Ann A2 - Nelson, Lewis S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Smith, Silas W. A2 - Goldfrank, Lewis R. A2 - Hoffman, Robert S. PY - 2019 T2 - Goldfrank's Toxicologic Emergencies, 11e AB - Methylene blue is an extremely effective antidote for acquired methemoglobinemia. Methylene blue has other actions, including the inhibition of nitric oxide synthase and guanylyl cyclase and the inhibition of the generation of oxygen free radicals. These actions likely explain the beneficial effects of methylene blue in the treatment of refractory hypotension, hepatopulmonary syndrome, priapism, sepsis, and malaria; the modulation of streptozocin-induced insulin deficiency; the prevention and treatment of ifosfamide-induced encephalopathy; and the reduction of the development of postsurgical peritoneal adhesions.15,16,21,24,34,44,53,64 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1163003951 ER -